Kevin Bennett

Associate Professor

Associate Chair

I have a broad interest in structural and functional microscopy and diagnostic imaging, wth a focus on molecular imaging . My lab develops new contrast agents and imaging strategies to sensitively detect physiological and cellular function with magnetic resonance imaging. Our current projects range from discovery science to translational medicine.

Contact

Room

EDM 309

Phone

(808) 956-8241

Fax

(808) 956-4745

Academic Degrees

PhD, Biophysics

Research Interests

Molecular imaging, magnetic resonance, biophysics, magnetic nanomaterials, self assembly, physiology, kidney disease

Current research support:

NIH/NIDDK R01 DK111861

NIH/NIDDK R01 DK110622

Selected Publications

Recent US patents: 

Kevin M. Bennett. Methods and compositions relating to reporter gels for use in MRI techniques. United States Patent 13/515,215. Nov 2017

Recent Peer reviewed journal articles: 

E. J. Baldelomar+, J.R. Charlton, S.C. Beeman, K.M. Bennett. Measuring rat kidney glomerular number and size in vivo with MRI. Am J Physiol Renal Physiol (in Press).

L. Xie, KM Bennett, C Liu, GA Johnson, JL Zhang, VS Lee. MR imaging tools for assessment of microstructure and concentrating function of the kidney. Am J Physiol Renal Physiol.2016;  311(6):F1109-F1124.

JR Charlton, V Pearl, AR Denotti, JB Lee, S. Swaminathan,  YM Scindia, NP Charlton, EJ Baldelomar, SC Beeman, and KM Bennett. Biocompatibility of ferritin-based nanoparticles as targeted MRI contrast agents. Nanomedicine 2016. 12(6); 1735-45.

B.D. Hann, E.J. Baldelomar, J.R. Charlton, K.M. Bennett. Measurig the intra-renal distribution of glomerular volumes from histologic sections. Am J Physiol Renal Physiol. 310(11), F1328-1336. 2016

M. Zhang, T. Wu, S.C. Beeman, L. Cullen-McEwen, J.F. Bertram, J.R. Charlton, E.J. Baldelomar, K.M. Bennett. Efficient small blob detection based on local convexity, intensity, and shape information. IEEE Trans Med Imaging IEEE Trans Med Imaging 2016. 35(4):1127-37.

K.M. Bennett. MRI shines (radiofrequency) light on kidney physiology.  Am J Physiol Renal Physiol. 2016; 310(1):F41-2

E. J. Baldelomar, J.R. Charlton, S.C. Beeman, L. Cullen-Mcewen, V.M. Pearl, J.F. Bertram, T. Wu, M. Zhang, K.M. Bennett. MRI phenotyping to nondestructively measure glomerular number and volume distribution in mice with and without nephron reduction. Kidney Int. 2016; 89(2): 498-505.

I. Aoki*, J-I Jo, H. Cabral, R. Bakalova, K.M. Bennett.  ナノDDS がもたらす新しいMRイメージングとナノ・セラノスティクス. Drug Deliv System (Japanese). 2015 30(1),47.

K.M. Bennett, S.C. Beeman, E.J. Baldelomar, M. Zhang, T. Wu, B.D. Hann, J.F. Bertram, and J.R. Charlton. Use of cationized ferritin nanoparticles to measure renal glomerular microstructure with MRI. In: Kidney Research: Experimental Protocols, eds hewitson TD, Smith ER, Holt SG. 2nd Edition, Humana Press. Springer, NY, USA, 2015.

M. Zhang, T. Wu, and K.M. Bennett. Small blob identification in medical images using regional features from optimum scale. IEEE Trans Biomed Eng. 2015. 62(4): 1051-62.

C. Qian, X. Yu, N. Pothayee, S. Dodd, N. Bouraoud, Y. Chen,  J. Murphy-Boesch, R.A. Star, K.M. Bennett, and A.P. Koretsky. Live nephron imaging by MRI.  AJP Renal Physiol. 2014. 307:F1162-F1168.

S.C. Beeman, L. Cullen-McEwen, M. Zhang, T. Wu, E.J. Baldelomar, J. Dowling, J.R. Charlton, M.S. Forbes, A. Ng, Q-Z Wu, J.A. Armitage, V.G. Puelles, G.F. Egan, J.F. Bertram, K.M. Bennett. MRI-based glomerular morphology and pathology in whole human kidneys. Am J Physiol Renal Physiol. , 2014. 306: F1381-F1390.

K.M. Bennett, J-I Jo, H. Cabral, B. Rumaiana, and I. Aoki. MR imaging techniques for nano-pathophysiology. Adv Drug Deliv Rev. 2014. 74C:75-94.

V. Clavijo Jordan ¸, E. Baldelomar, S.C. Beeman, and K.M. Bennett. Disruptive chemical doping in a ferritin-based iron oxide nanoparticle to decrease r2 and enhance detection with T1-weighted MRI. Contrast Media and Molecular Imaging. 2014.  9(4): 323-332. 

J.F. Bertram, L.A. Cullen-McEwen, G. Egan, N. Gretz, E. Baldelomar, S.C. Beeman, and K.M. Bennett. How and why we measure nephron number. Pediatric Nephrology. 2014. 29(4); 575-580.